ID | Label | % in cluster | Enrichment log2 | p-value | Corrected p-value |
---|---|---|---|---|---|
GO:0034641 | cellular nitrogen compound metabolic process | 37.08% (66/178) | 3.34 | 0.0 | 0.0 |
GO:0043043 | peptide biosynthetic process | 26.4% (47/178) | 5.14 | 0.0 | 0.0 |
GO:0043228 | non-membrane-bounded organelle | 25.28% (45/178) | 4.77 | 0.0 | 0.0 |
GO:0043232 | intracellular non-membrane-bounded organelle | 25.28% (45/178) | 4.77 | 0.0 | 0.0 |
GO:0043603 | cellular amide metabolic process | 26.97% (48/178) | 5.0 | 0.0 | 0.0 |
GO:1901566 | organonitrogen compound biosynthetic process | 30.34% (54/178) | 4.55 | 0.0 | 0.0 |
GO:0043604 | amide biosynthetic process | 26.97% (48/178) | 5.14 | 0.0 | 0.0 |
GO:0006518 | peptide metabolic process | 26.4% (47/178) | 5.09 | 0.0 | 0.0 |
GO:0006412 | translation | 26.4% (47/178) | 5.18 | 0.0 | 0.0 |
GO:0005840 | ribosome | 25.28% (45/178) | 5.18 | 0.0 | 0.0 |
GO:0044271 | cellular nitrogen compound biosynthetic process | 29.21% (52/178) | 3.9 | 0.0 | 0.0 |
GO:0005198 | structural molecule activity | 26.4% (47/178) | 5.03 | 0.0 | 0.0 |
GO:0003735 | structural constituent of ribosome | 26.4% (47/178) | 5.16 | 0.0 | 0.0 |
GO:0034645 | cellular macromolecule biosynthetic process | 26.4% (47/178) | 4.1 | 0.0 | 0.0 |
GO:0044249 | cellular biosynthetic process | 31.46% (56/178) | 3.58 | 0.0 | 0.0 |
GO:1901576 | organic substance biosynthetic process | 31.46% (56/178) | 3.56 | 0.0 | 0.0 |
GO:0009058 | biosynthetic process | 32.58% (58/178) | 3.42 | 0.0 | 0.0 |
GO:0009059 | macromolecule biosynthetic process | 26.4% (47/178) | 3.96 | 0.0 | 0.0 |
GO:1901564 | organonitrogen compound metabolic process | 33.71% (60/178) | 3.11 | 0.0 | 0.0 |
GO:0044267 | cellular protein metabolic process | 26.97% (48/178) | 3.66 | 0.0 | 0.0 |
GO:0044237 | cellular metabolic process | 40.45% (72/178) | 2.66 | 0.0 | 0.0 |
GO:0043226 | organelle | 26.4% (47/178) | 3.68 | 0.0 | 0.0 |
GO:0043229 | intracellular organelle | 26.4% (47/178) | 3.68 | 0.0 | 0.0 |
GO:0006807 | nitrogen compound metabolic process | 37.64% (67/178) | 2.64 | 0.0 | 0.0 |
GO:0019538 | protein metabolic process | 26.97% (48/178) | 3.32 | 0.0 | 0.0 |
GO:0044238 | primary metabolic process | 38.2% (68/178) | 2.35 | 0.0 | 0.0 |
GO:0044260 | cellular macromolecule metabolic process | 28.09% (50/178) | 2.93 | 0.0 | 0.0 |
GO:0043170 | macromolecule metabolic process | 32.02% (57/178) | 2.65 | 0.0 | 0.0 |
GO:0071704 | organic substance metabolic process | 38.76% (69/178) | 2.26 | 0.0 | 0.0 |
GO:0008152 | metabolic process | 44.94% (80/178) | 1.92 | 0.0 | 0.0 |
GO:0009987 | cellular process | 41.57% (74/178) | 1.89 | 0.0 | 0.0 |
GO:0003674 | molecular_function | 57.87% (103/178) | 1.16 | 0.0 | 0.0 |
GO:0110165 | cellular anatomical entity | 27.53% (49/178) | 2.16 | 0.0 | 0.0 |
GO:0008150 | biological_process | 46.63% (83/178) | 1.38 | 0.0 | 0.0 |
GO:0005575 | cellular_component | 29.21% (52/178) | 1.95 | 0.0 | 0.0 |
GO:0003723 | RNA binding | 6.74% (12/178) | 3.19 | 0.0 | 0.0 |
GO:0044281 | small molecule metabolic process | 7.87% (14/178) | 2.67 | 0.0 | 0.0 |
GO:0019843 | rRNA binding | 2.25% (4/178) | 5.25 | 1e-06 | 1.4e-05 |
GO:0006725 | cellular aromatic compound metabolic process | 10.11% (18/178) | 1.83 | 3e-06 | 3.1e-05 |
GO:0046483 | heterocycle metabolic process | 10.11% (18/178) | 1.82 | 3e-06 | 3.2e-05 |
GO:1901360 | organic cyclic compound metabolic process | 10.11% (18/178) | 1.75 | 6e-06 | 6e-05 |
GO:0005488 | binding | 25.84% (46/178) | 0.87 | 2.2e-05 | 0.000201 |
GO:1901363 | heterocyclic compound binding | 19.66% (35/178) | 1.05 | 2.4e-05 | 0.00021 |
GO:0097159 | organic cyclic compound binding | 19.66% (35/178) | 1.05 | 2.4e-05 | 0.00021 |
GO:0055086 | nucleobase-containing small molecule metabolic process | 3.37% (6/178) | 3.33 | 2.4e-05 | 0.000214 |
GO:0052803 | imidazole-containing compound metabolic process | 1.69% (3/178) | 5.1 | 5.1e-05 | 0.000418 |
GO:0000105 | histidine biosynthetic process | 1.69% (3/178) | 5.1 | 5.1e-05 | 0.000418 |
GO:0006547 | histidine metabolic process | 1.69% (3/178) | 5.1 | 5.1e-05 | 0.000418 |
GO:0006139 | nucleobase-containing compound metabolic process | 8.43% (15/178) | 1.69 | 6.2e-05 | 0.000493 |
GO:0016874 | ligase activity | 3.37% (6/178) | 2.87 | 0.000156 | 0.00122 |
GO:0043436 | oxoacid metabolic process | 3.93% (7/178) | 2.45 | 0.000275 | 0.002025 |
GO:0006082 | organic acid metabolic process | 3.93% (7/178) | 2.45 | 0.000275 | 0.002025 |
GO:0019752 | carboxylic acid metabolic process | 3.93% (7/178) | 2.45 | 0.000275 | 0.002025 |
GO:0046394 | carboxylic acid biosynthetic process | 2.25% (4/178) | 3.59 | 0.000286 | 0.002031 |
GO:0016053 | organic acid biosynthetic process | 2.25% (4/178) | 3.59 | 0.000286 | 0.002031 |
GO:0009073 | aromatic amino acid family biosynthetic process | 1.69% (3/178) | 4.25 | 0.000409 | 0.002857 |
GO:0003676 | nucleic acid binding | 10.67% (19/178) | 1.24 | 0.00042 | 0.002878 |
GO:0006520 | cellular amino acid metabolic process | 3.37% (6/178) | 2.59 | 0.000456 | 0.003076 |
GO:0034660 | ncRNA metabolic process | 3.37% (6/178) | 2.56 | 0.000502 | 0.003324 |
GO:0032553 | ribonucleotide binding | 8.99% (16/178) | 1.35 | 0.000533 | 0.003475 |
GO:0097367 | carbohydrate derivative binding | 8.99% (16/178) | 1.32 | 0.000678 | 0.004343 |
GO:0016879 | ligase activity, forming carbon-nitrogen bonds | 1.69% (3/178) | 3.96 | 0.000783 | 0.00494 |
GO:0035639 | purine ribonucleoside triphosphate binding | 8.43% (15/178) | 1.32 | 0.000994 | 0.006169 |
GO:1901607 | alpha-amino acid biosynthetic process | 1.69% (3/178) | 3.84 | 0.001031 | 0.006202 |
GO:0009072 | aromatic amino acid family metabolic process | 1.69% (3/178) | 3.84 | 0.001031 | 0.006202 |
GO:0032555 | purine ribonucleotide binding | 8.43% (15/178) | 1.31 | 0.001085 | 0.006332 |
GO:0006399 | tRNA metabolic process | 2.81% (5/178) | 2.67 | 0.001074 | 0.006361 |
GO:0017076 | purine nucleotide binding | 8.43% (15/178) | 1.29 | 0.001218 | 0.007001 |
GO:0072522 | purine-containing compound biosynthetic process | 1.69% (3/178) | 3.61 | 0.001662 | 0.00942 |
GO:0016742 | hydroxymethyl-, formyl- and related transferase activity | 1.12% (2/178) | 4.84 | 0.001784 | 0.009966 |
GO:0090079 | translation regulator activity, nucleic acid binding | 1.69% (3/178) | 3.52 | 0.002051 | 0.010988 |
GO:0045182 | translation regulator activity | 1.69% (3/178) | 3.52 | 0.002051 | 0.010988 |
GO:0008135 | translation factor activity, RNA binding | 1.69% (3/178) | 3.52 | 0.002051 | 0.010988 |
GO:0044283 | small molecule biosynthetic process | 2.25% (4/178) | 2.84 | 0.002221 | 0.011733 |
GO:0008652 | cellular amino acid biosynthetic process | 1.69% (3/178) | 3.42 | 0.002493 | 0.012995 |
GO:1901265 | nucleoside phosphate binding | 9.55% (17/178) | 1.07 | 0.003059 | 0.015532 |
GO:0000166 | nucleotide binding | 9.55% (17/178) | 1.07 | 0.003059 | 0.015532 |
GO:0072521 | purine-containing compound metabolic process | 1.69% (3/178) | 3.25 | 0.00354 | 0.017745 |
GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 1.69% (3/178) | 3.17 | 0.00415 | 0.02054 |
GO:0005524 | ATP binding | 6.74% (12/178) | 1.27 | 0.004295 | 0.02099 |
GO:0032559 | adenyl ribonucleotide binding | 6.74% (12/178) | 1.25 | 0.004666 | 0.022525 |
GO:0030554 | adenyl nucleotide binding | 6.74% (12/178) | 1.24 | 0.004928 | 0.023499 |
GO:0140101 | catalytic activity, acting on a tRNA | 2.25% (4/178) | 2.52 | 0.005064 | 0.023855 |
GO:0036094 | small molecule binding | 9.55% (17/178) | 0.98 | 0.005738 | 0.02671 |
GO:1901135 | carbohydrate derivative metabolic process | 2.25% (4/178) | 2.44 | 0.006037 | 0.02713 |
GO:1901657 | glycosyl compound metabolic process | 1.12% (2/178) | 4.03 | 0.006032 | 0.027425 |
GO:0009116 | nucleoside metabolic process | 1.12% (2/178) | 4.03 | 0.006032 | 0.027425 |
GO:1901605 | alpha-amino acid metabolic process | 1.69% (3/178) | 2.96 | 0.006347 | 0.027884 |
GO:0019438 | aromatic compound biosynthetic process | 3.93% (7/178) | 1.68 | 0.006298 | 0.027985 |
GO:0018130 | heterocycle biosynthetic process | 3.93% (7/178) | 1.64 | 0.007149 | 0.031058 |
GO:0006418 | tRNA aminoacylation for protein translation | 1.69% (3/178) | 2.84 | 0.008131 | 0.034938 |
GO:0008144 | drug binding | 6.74% (12/178) | 1.1 | 0.010221 | 0.043439 |
GO:1901362 | organic cyclic compound biosynthetic process | 3.93% (7/178) | 1.54 | 0.010605 | 0.044586 |
GO:0016875 | ligase activity, forming carbon-oxygen bonds | 1.69% (3/178) | 2.67 | 0.01131 | 0.045125 |
GO:0004812 | aminoacyl-tRNA ligase activity | 1.69% (3/178) | 2.67 | 0.01131 | 0.045125 |
GO:0043039 | tRNA aminoacylation | 1.69% (3/178) | 2.67 | 0.01131 | 0.045125 |
GO:0043038 | amino acid activation | 1.69% (3/178) | 2.67 | 0.01131 | 0.045125 |
GO:0043168 | anion binding | 8.99% (16/178) | 0.92 | 0.010904 | 0.045356 |
Clade | % in cluster | Enrichment log2 | p-value | Corrected p-value | Gene Family Method |
---|---|---|---|---|---|
No enriched Clades found |
Species | Clustering Method | Target | Jaccard index | Gene Family Method (for comparison) | Actions |
---|---|---|---|---|---|
Saccharomyces cerevisiae | HCCA | Cluster_7 | 0.028 | OF | Compare |
Saccharomyces cerevisiae | HCCA | Cluster_8 | 0.024 | OF | Compare |
Saccharomyces cerevisiae | HCCA | Cluster_13 | 0.054 | OF | Compare |
Saccharomyces cerevisiae | HCCA | Cluster_16 | 0.037 | OF | Compare |
Saccharomyces cerevisiae | HCCA | Cluster_22 | 0.164 | OF | Compare |
Saccharomyces cerevisiae | HCCA | Cluster_27 | 0.057 | OF | Compare |
Saccharomyces cerevisiae | HCCA | Cluster_31 | 0.032 | OF | Compare |
Saccharomyces cerevisiae | HCCA | Cluster_49 | 0.018 | OF | Compare |
Saccharomyces cerevisiae | HCCA | Cluster_69 | 0.074 | OF | Compare |
Aspergillus flavus | HCCA | Cluster_9 | 0.055 | OF | Compare |
Aspergillus fumigatus | HCCA | Cluster_7 | 0.086 | OF | Compare |
Aspergillus fumigatus | HCCA | Cluster_16 | 0.026 | OF | Compare |
Aspergillus fumigatus | HCCA | Cluster_23 | 0.282 | OF | Compare |
Aspergillus fumigatus | HCCA | Cluster_28 | 0.033 | OF | Compare |
Aspergillus fumigatus | HCCA | Cluster_51 | 0.033 | OF | Compare |
Aspergillus fumigatus | HCCA | Cluster_66 | 0.053 | OF | Compare |
Aspergillus fumigatus | HCCA | Cluster_96 | 0.027 | OF | Compare |
Aspergillus nidulans | HCCA | Cluster_11 | 0.02 | OF | Compare |
Aspergillus nidulans | HCCA | Cluster_25 | 0.273 | OF | Compare |
Aspergillus nidulans | HCCA | Cluster_27 | 0.092 | OF | Compare |
Aspergillus nidulans | HCCA | Cluster_46 | 0.03 | OF | Compare |
Aspergillus nidulans | HCCA | Cluster_49 | 0.022 | OF | Compare |
Aspergillus nidulans | HCCA | Cluster_55 | 0.034 | OF | Compare |
Aspergillus nidulans | HCCA | Cluster_96 | 0.036 | OF | Compare |
Aspergillus niger | HCCA | Cluster_2 | 0.037 | OF | Compare |
Aspergillus niger | HCCA | Cluster_22 | 0.1 | OF | Compare |
Aspergillus niger | HCCA | Cluster_26 | 0.046 | OF | Compare |
Aspergillus niger | HCCA | Cluster_35 | 0.02 | OF | Compare |
Aspergillus niger | HCCA | Cluster_44 | 0.023 | OF | Compare |
Aspergillus niger | HCCA | Cluster_50 | 0.182 | OF | Compare |
Aspergillus niger | HCCA | Cluster_67 | 0.02 | OF | Compare |
Aspergillus niger | HCCA | Cluster_84 | 0.043 | OF | Compare |
Candida albicans | HCCA | Cluster_7 | 0.037 | OF | Compare |
Candida albicans | HCCA | Cluster_13 | 0.053 | OF | Compare |
Candida albicans | HCCA | Cluster_15 | 0.035 | OF | Compare |
Candida albicans | HCCA | Cluster_18 | 0.251 | OF | Compare |
Candida albicans | HCCA | Cluster_21 | 0.022 | OF | Compare |
Candida albicans | HCCA | Cluster_31 | 0.032 | OF | Compare |
Candida albicans | HCCA | Cluster_39 | 0.034 | OF | Compare |
Candida albicans | HCCA | Cluster_53 | 0.033 | OF | Compare |
Coprinopsis cinerea | HCCA | Cluster_23 | 0.034 | OF | Compare |
Coprinopsis cinerea | HCCA | Cluster_42 | 0.107 | OF | Compare |
Coprinopsis cinerea | HCCA | Cluster_76 | 0.025 | OF | Compare |
Coprinopsis cinerea | HCCA | Cluster_86 | 0.019 | OF | Compare |
Coprinopsis cinerea | HCCA | Cluster_99 | 0.072 | OF | Compare |
Coprinopsis cinerea | HCCA | Cluster_103 | 0.028 | OF | Compare |
Coprinopsis cinerea | HCCA | Cluster_120 | 0.021 | OF | Compare |
Cryptococcus neoformans | HCCA | Cluster_1 | 0.019 | OF | Compare |
Cryptococcus neoformans | HCCA | Cluster_13 | 0.094 | OF | Compare |
Cryptococcus neoformans | HCCA | Cluster_26 | 0.025 | OF | Compare |
Cryptococcus neoformans | HCCA | Cluster_28 | 0.229 | OF | Compare |
Cryptococcus neoformans | HCCA | Cluster_30 | 0.035 | OF | Compare |
Cryptococcus neoformans | HCCA | Cluster_53 | 0.017 | OF | Compare |
Cryptococcus neoformans | HCCA | Cluster_55 | 0.056 | OF | Compare |
Cryptococcus neoformans | HCCA | Cluster_61 | 0.018 | OF | Compare |
Dichomitus squalens | HCCA | Cluster_38 | 0.1 | OF | Compare |
Fusarium graminearum | HCCA | Cluster_19 | 0.04 | OF | Compare |
Fusarium graminearum | HCCA | Cluster_37 | 0.035 | OF | Compare |
Fusarium graminearum | HCCA | Cluster_38 | 0.261 | OF | Compare |
Fusarium graminearum | HCCA | Cluster_39 | 0.018 | OF | Compare |
Fusarium graminearum | HCCA | Cluster_40 | 0.087 | OF | Compare |
Fusarium graminearum | HCCA | Cluster_42 | 0.018 | OF | Compare |
Fusarium graminearum | HCCA | Cluster_77 | 0.033 | OF | Compare |
Fusarium graminearum | HCCA | Cluster_95 | 0.048 | OF | Compare |
Fusarium graminearum | HCCA | Cluster_112 | 0.069 | OF | Compare |
Komagataella phaffii | HCCA | Cluster_1 | 0.066 | OF | Compare |
Komagataella phaffii | HCCA | Cluster_4 | 0.021 | OF | Compare |
Komagataella phaffii | HCCA | Cluster_7 | 0.245 | OF | Compare |
Komagataella phaffii | HCCA | Cluster_14 | 0.041 | OF | Compare |
Komagataella phaffii | HCCA | Cluster_17 | 0.02 | OF | Compare |
Komagataella phaffii | HCCA | Cluster_18 | 0.04 | OF | Compare |
Komagataella phaffii | HCCA | Cluster_31 | 0.018 | OF | Compare |
Komagataella phaffii | HCCA | Cluster_41 | 0.02 | OF | Compare |
Komagataella phaffii | HCCA | Cluster_50 | 0.018 | OF | Compare |
Komagataella phaffii | HCCA | Cluster_55 | 0.018 | OF | Compare |
Neurospora crassa | HCCA | Cluster_2 | 0.242 | OF | Compare |
Neurospora crassa | HCCA | Cluster_3 | 0.018 | OF | Compare |
Neurospora crassa | HCCA | Cluster_10 | 0.048 | OF | Compare |
Neurospora crassa | HCCA | Cluster_21 | 0.02 | OF | Compare |
Neurospora crassa | HCCA | Cluster_22 | 0.028 | OF | Compare |
Neurospora crassa | HCCA | Cluster_26 | 0.038 | OF | Compare |
Neurospora crassa | HCCA | Cluster_34 | 0.069 | OF | Compare |
Neurospora crassa | HCCA | Cluster_45 | 0.03 | OF | Compare |
Neurospora crassa | HCCA | Cluster_51 | 0.038 | OF | Compare |
Postia placenta | HCCA | Cluster_1 | 0.034 | OF | Compare |
Postia placenta | HCCA | Cluster_10 | 0.037 | OF | Compare |
Postia placenta | HCCA | Cluster_22 | 0.179 | OF | Compare |
Postia placenta | HCCA | Cluster_61 | 0.022 | OF | Compare |
Postia placenta | HCCA | Cluster_66 | 0.036 | OF | Compare |
Puccinia striiformis | HCCA | Cluster_15 | 0.033 | OF | Compare |
Puccinia striiformis | HCCA | Cluster_21 | 0.2 | OF | Compare |
Puccinia striiformis | HCCA | Cluster_26 | 0.037 | OF | Compare |
Puccinia striiformis | HCCA | Cluster_55 | 0.027 | OF | Compare |
Puccinia striiformis | HCCA | Cluster_78 | 0.023 | OF | Compare |
Puccinia striiformis | HCCA | Cluster_79 | 0.023 | OF | Compare |
Pyricularia oryzae | HCCA | Cluster_1 | 0.024 | OF | Compare |
Pyricularia oryzae | HCCA | Cluster_43 | 0.019 | OF | Compare |
Pyricularia oryzae | HCCA | Cluster_44 | 0.182 | OF | Compare |
Pyricularia oryzae | HCCA | Cluster_49 | 0.023 | OF | Compare |
Pyricularia oryzae | HCCA | Cluster_73 | 0.034 | OF | Compare |
Pyricularia oryzae | HCCA | Cluster_83 | 0.032 | OF | Compare |
Pyricularia oryzae | HCCA | Cluster_85 | 0.018 | OF | Compare |
Pyricularia oryzae | HCCA | Cluster_86 | 0.026 | OF | Compare |
Pyricularia oryzae | HCCA | Cluster_88 | 0.054 | OF | Compare |
Pyricularia oryzae | HCCA | Cluster_90 | 0.036 | OF | Compare |
Pyricularia oryzae | HCCA | Cluster_114 | 0.032 | OF | Compare |
Yarrowia lipolytica | HCCA | Cluster_3 | 0.025 | OF | Compare |
Yarrowia lipolytica | HCCA | Cluster_9 | 0.145 | OF | Compare |
Yarrowia lipolytica | HCCA | Cluster_21 | 0.025 | OF | Compare |
Yarrowia lipolytica | HCCA | Cluster_24 | 0.027 | OF | Compare |
Yarrowia lipolytica | HCCA | Cluster_25 | 0.02 | OF | Compare |
Yarrowia lipolytica | HCCA | Cluster_31 | 0.07 | OF | Compare |
Yarrowia lipolytica | HCCA | Cluster_52 | 0.149 | OF | Compare |
Yarrowia lipolytica | HCCA | Cluster_67 | 0.021 | OF | Compare |
Schizosaccharomyces pombe | HCCA | Cluster_10 | 0.224 | OF | Compare |
Schizosaccharomyces pombe | HCCA | Cluster_13 | 0.023 | OF | Compare |
Schizosaccharomyces pombe | HCCA | Cluster_14 | 0.018 | OF | Compare |
Schizosaccharomyces pombe | HCCA | Cluster_19 | 0.024 | OF | Compare |
Schizosaccharomyces pombe | HCCA | Cluster_22 | 0.024 | OF | Compare |
Schizosaccharomyces pombe | HCCA | Cluster_34 | 0.017 | OF | Compare |
Schizosaccharomyces pombe | HCCA | Cluster_36 | 0.035 | OF | Compare |
Schizosaccharomyces pombe | HCCA | Cluster_37 | 0.018 | OF | Compare |
Schizosaccharomyces pombe | HCCA | Cluster_41 | 0.021 | OF | Compare |
Schizosaccharomyces pombe | HCCA | Cluster_49 | 0.022 | OF | Compare |
Trichoderma reesei | HCCA | Cluster_3 | 0.027 | OF | Compare |
Trichoderma reesei | HCCA | Cluster_12 | 0.048 | OF | Compare |
Trichoderma reesei | HCCA | Cluster_21 | 0.02 | OF | Compare |
Trichoderma reesei | HCCA | Cluster_30 | 0.261 | OF | Compare |
Trichoderma reesei | HCCA | Cluster_40 | 0.022 | OF | Compare |
Trichoderma reesei | HCCA | Cluster_46 | 0.021 | OF | Compare |
Trichoderma reesei | HCCA | Cluster_49 | 0.018 | OF | Compare |
Trichoderma reesei | HCCA | Cluster_53 | 0.019 | OF | Compare |
Trichoderma reesei | HCCA | Cluster_64 | 0.018 | OF | Compare |
Trichoderma reesei | HCCA | Cluster_85 | 0.027 | OF | Compare |